| Jugador | Equipo | Goles |
|---|---|---|
 Diego Tardelli |
 Atlético Mineiro |
6 |
| Jô |
Atlético Mineiro |
6 |
| Ignacio Scocco |
 Newell`s |
5 |
| Braian Rodríguez |
 Huachipato |
5 |
| Fredy J. Bareiro |
 Olimpia |
5 |
| Luis Fabiano |
 Sao Paulo |
5 |
| Ronaldinho |
Atlético Mineiro |
4 |
| Fidel Martinez Tenorio |
 Tijuana |
4 |
| Rogerio L. Leichtweis |
 Tolima |
4 |
| Matías Pérez García |
 Tigre |
4 |
| Irven B. Ávila |
 Sporting Cristal |
4 |
| Rubén A. Botta |
Tigre |
4 |
| Paolo Guerrero |
 Corinthians |
4 |
| Cristian Martínez Borja |
 Santa Fe |
4 |
| Jadson |
Sao Paulo |
4 |
| Manuel Villalobos |
 Deportes Iquique |
4 |
| Rogério Ceni |
Sao Paulo |
3 |
| Omar Pérez |
Santa Fe |
3 |
| Darío I. Benedetto |
 Arsenal |
3 |
| Juan C. Ferreyra |
Olimpia |
3 |